COLUMBUS - Seventh-ranked Ohio State handed Pittsburgh its worst loss ever, pounding the Panthers, 72-0, Saturday behind three touchdowns apiece by Pepe Pearson and freshman David Boston.
The Buckeyes scored on their first 10 possessions, outgained the Panthers 602-120 in total yards and had a 29-4 advantage in first downs.
In 107 years of football, Pittsburgh (1-3) had never given up more points or been beaten by a bigger margin.
The Buckeyes (2-0), who routed Rice, 70-7, two weeks ago in their opener, have scored 142 points in their first two games. That matches the most points ever by Ohio State in back-to-back games.
Harris also made a couple of key blocks that set up two other scores for Penn State (4-0).
The shutout was the second straight for Penn State, and it extended its unbeaten streak against the Owls (1-3) to 29 consecutive games, including 21 in a row.
Bill Manopolous missed a 43-yard field goal in the third quarter and a 30-yarder in the fourth quarter for Indiana (2-1).
Holcombe scored on runs of one, six and 31 yards in the second half Saturday as the Illini (1-3) turned a 7-7 halftime tie into a rout of the Zips (0-4).
Northwestern (2-1) built a 28-0 halftime lead, holding the Bobcats' triple-option attack to 56 yards.
Ohio (2-2) finished with seven passing yards and four turnovers.
Despite throwing three second-half interceptions, Badgers' quarterback Mike Samuel sealed the victory with a 1-yard sneak with 1:50 remaining, giving Wisconsin its first 3-0 start since 1993.
West Virginia (4-0), which had not allowed a rushing touchdown this season, did not let Purdue (0-3) inside the 25 until early in the fourth quarter, after a short punt gave the Boilermakers the ball at the 39.
Tulsa (1-2) came from behind Saturday night to pull out its first victory over a ranked opponent since beating No. 15 Texas A&M in 1991.
The Tulsa defense held Iowa (2-1) twice within the 10-yard line in the fourth quarter.
The Golden Gophers (3-0) wasted a 29-12 lead before Sauter led them to two Adam Bailey field goals in the final 5:23, including the winner with 42 seconds left in a 35-33 victory over No. 23 Syracuse (0-2).
Tavian Banks and Iowa were upended by Tulsa on Saturday, 27-20. With the loss, the Hawkeyes fell out of the AP top 25.