Billups, a second-team All-American, scored 20 points in the first half as Colorado built a 46-31 lead. The Buffaloes (22-9), making their first NCAA appearance in 28 years, went on to beat Indiana (22-11) by 18 points, matching the Hoosier's worst NCAA tournament defeat in 71 games.
Purdue 83, Rhode Island 76, OT
Brad Miller had a career-high 31 points and eight rebounds and Purdue scored the first six points in overtime.
Freshman Brian Cardinal, whose 3-pointer with 16 seconds left in regulation forced OT, hit the first basket in the extra period, and Purdue (18-11) never trailed again.
The Rams (20-9) had their chances to win in regulation. But Tyson Wheeler's leaner bounced off, and Michael Andersen missed the follow before the buzzer.
Iowa 73, Virginia 60
Guy Rucker scored 19 points and Andrew Woolridge added 17 as Iowa coach Tom Davis improved to 10-0 in first-round games.
Iowa (22-9) never trailed and led by as many as 22 points in the second half before a late scoring spurt by Virginia's Harold Deane cut the final margin.
Kansas 78, Jackson St. 64
Scot Pollard, coming back from a broken foot, grabbed a career-high 19 rebounds to go with six blocks and 12 points in top-ranked Kansas' victory.
Pollard, All-American Raef LaFrentz and Paul Pierce overwhelmed 16th-seeded Jackson State. LaFrentz had 18 points, 14 rebounds and three blocks, and Pierce had 19 points, 13 rebounds and four blocks as Kansas (33-1) had a 61-27 rebounding advantage.
Kentucky 92, Montana 54
Cameron Mills scored 19 points, his third consecutive career high, as the defending national champions routed Montana.
Wayne Turner also scored 19 for Kentucky (31-4) , while Ron Mercer added 16. Bob Olson and Ryan Dick scored 10 apiece for Montana (21-11).
Boston College 73, Valparaiso 66
Bevan Thomas came off the bench to score 11 of his 16 points in the second half as BC overcame a long-range shooting barrage by Bryce Drew. Danya Abrams also scored 16 points and grabbed 12 rebounds for the fifth-seeded Eagles.
Drew, the sharpshooting son of coach Homer Drew, scored 27 points, including 8-of-12 3-pointers. But he was shut down by a smothering box-and-one defense through most of the second half, when he was held to eight points.